Review





Similar Products

nd normal diet labdiet 5001  (PMI Nutrition International LLC)
99
PMI Nutrition International LLC nd normal diet labdiet 5001
Nd Normal Diet Labdiet 5001, supplied by PMI Nutrition International LLC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+diet+nd/pmc12964532-52-22-25?v=PMI+Nutrition+International+LLC
Average 99 stars, based on 1 article reviews
nd normal diet labdiet 5001 - by Bioz Stars, 2026-07
99/100 stars
  Buy from Supplier
normal diet nd  (PMI Nutrition International LLC)
99
PMI Nutrition International LLC normal diet nd
Normal Diet Nd, supplied by PMI Nutrition International LLC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+diet+nd/bio_rxiv__64898__2026__01__05__697779-185-15-22?v=PMI+Nutrition+International+LLC
Average 99 stars, based on 1 article reviews
normal diet nd - by Bioz Stars, 2026-07
99/100 stars
  Buy from Supplier
normal chow diet nd  (PMI Nutrition International LLC)
99
PMI Nutrition International LLC normal chow diet nd
Seven-week-old male Ldl receptor -deficient ( Ldlr -/- ) mice were treated with tsRNA-Glu-CTC antisense oligonucleotides (ASO) or control ASO twice per week for 7 weeks. The mice were maintained on a <t>normal</t> <t>chow</t> <t>diet</t> (ND) or switched to a high-cholesterol diet (HCD) starting at 8-week-old age. a The schematic of tsRNA-Glu-CTC ASO treatment experiment. Created in BioRender. Zhou, C. ( https://BioRender.com/rj9jwzr ). b – g Body weight ( n = 8,10,10) ( b ), representative photos of collected serum ( c ), serum total cholesterol ( n = 8,10,10) (left panel) and triglyceride ( n = 5,10,10) (right panel) levels ( d ), cholesterol levels of lipoprotein fractions (VLDL-C, LDL-C, and HDL-C) ( n = 8,10,10) ( e ), representative Oil-Red-O (top) and hematoxylin and eosin (bottom) stained liver sections (scale bar =100 μm) ( f ), and hepatic cholesterol ( n = 6,9,6) (left panel) and triglyceride ( n = 6,8,6) (right panel) contents ( g ) of Ldlr -/- mice treated with vehicle control, control ASO, or tsRNA-Glu-CTC ASO (data are shown as mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). h Representative images of Oil-red-O-stained sections and quantitative analysis of the atherosclerotic lesion area at the aortic root of Ldlr -/- mice ( n = 7,8,8; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). i Correlation between serum total cholesterol levels and atherosclerotic lesion sizes in Ldlr -/- mice ( n = 16; Correlation was analyzed by Pearson correlation). j Representative images of immunofluorescence staining of CD68 (green) and α-smooth muscle actin (αSMA) (red) at the aortic root of Ldlr -/- mice (scale bar=200 µm). Quantitative analysis of staining area is displayed as indicated ( n = 6,6,6; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). k The expression levels of hepatic lipogenic genes of HCD-fed Ldlr -/- mice treated with tsRNA-Glu-CTC ASO or control ASO were analyzed by quantitative real-time PCR ( n = 6, mean ± SEM, two-tailed Student’s t-test). n represents the number of biological replicates (mice). VLDL-C very low-density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol.
Normal Chow Diet Nd, supplied by PMI Nutrition International LLC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+diet+nd/pmc12706008-381-6-10?v=PMI+Nutrition+International+LLC
Average 99 stars, based on 1 article reviews
normal chow diet nd - by Bioz Stars, 2026-07
99/100 stars
  Buy from Supplier
normal diet [nd] safe a03  (SAS institute)
90
SAS institute normal diet [nd] safe a03
Seven-week-old male Ldl receptor -deficient ( Ldlr -/- ) mice were treated with tsRNA-Glu-CTC antisense oligonucleotides (ASO) or control ASO twice per week for 7 weeks. The mice were maintained on a <t>normal</t> <t>chow</t> <t>diet</t> (ND) or switched to a high-cholesterol diet (HCD) starting at 8-week-old age. a The schematic of tsRNA-Glu-CTC ASO treatment experiment. Created in BioRender. Zhou, C. ( https://BioRender.com/rj9jwzr ). b – g Body weight ( n = 8,10,10) ( b ), representative photos of collected serum ( c ), serum total cholesterol ( n = 8,10,10) (left panel) and triglyceride ( n = 5,10,10) (right panel) levels ( d ), cholesterol levels of lipoprotein fractions (VLDL-C, LDL-C, and HDL-C) ( n = 8,10,10) ( e ), representative Oil-Red-O (top) and hematoxylin and eosin (bottom) stained liver sections (scale bar =100 μm) ( f ), and hepatic cholesterol ( n = 6,9,6) (left panel) and triglyceride ( n = 6,8,6) (right panel) contents ( g ) of Ldlr -/- mice treated with vehicle control, control ASO, or tsRNA-Glu-CTC ASO (data are shown as mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). h Representative images of Oil-red-O-stained sections and quantitative analysis of the atherosclerotic lesion area at the aortic root of Ldlr -/- mice ( n = 7,8,8; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). i Correlation between serum total cholesterol levels and atherosclerotic lesion sizes in Ldlr -/- mice ( n = 16; Correlation was analyzed by Pearson correlation). j Representative images of immunofluorescence staining of CD68 (green) and α-smooth muscle actin (αSMA) (red) at the aortic root of Ldlr -/- mice (scale bar=200 µm). Quantitative analysis of staining area is displayed as indicated ( n = 6,6,6; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). k The expression levels of hepatic lipogenic genes of HCD-fed Ldlr -/- mice treated with tsRNA-Glu-CTC ASO or control ASO were analyzed by quantitative real-time PCR ( n = 6, mean ± SEM, two-tailed Student’s t-test). n represents the number of biological replicates (mice). VLDL-C very low-density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol.
Normal Diet [Nd] Safe A03, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+diet+nd/bio_rxiv__2025__06__10__658894-34-12-25?v=SAS+institute
Average 90 stars, based on 1 article reviews
normal diet [nd] safe a03 - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier
normal rodent diet (nd: envigo 2018s)  (Envigo)
90
Envigo normal rodent diet (nd: envigo 2018s)
Seven-week-old male Ldl receptor -deficient ( Ldlr -/- ) mice were treated with tsRNA-Glu-CTC antisense oligonucleotides (ASO) or control ASO twice per week for 7 weeks. The mice were maintained on a <t>normal</t> <t>chow</t> <t>diet</t> (ND) or switched to a high-cholesterol diet (HCD) starting at 8-week-old age. a The schematic of tsRNA-Glu-CTC ASO treatment experiment. Created in BioRender. Zhou, C. ( https://BioRender.com/rj9jwzr ). b – g Body weight ( n = 8,10,10) ( b ), representative photos of collected serum ( c ), serum total cholesterol ( n = 8,10,10) (left panel) and triglyceride ( n = 5,10,10) (right panel) levels ( d ), cholesterol levels of lipoprotein fractions (VLDL-C, LDL-C, and HDL-C) ( n = 8,10,10) ( e ), representative Oil-Red-O (top) and hematoxylin and eosin (bottom) stained liver sections (scale bar =100 μm) ( f ), and hepatic cholesterol ( n = 6,9,6) (left panel) and triglyceride ( n = 6,8,6) (right panel) contents ( g ) of Ldlr -/- mice treated with vehicle control, control ASO, or tsRNA-Glu-CTC ASO (data are shown as mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). h Representative images of Oil-red-O-stained sections and quantitative analysis of the atherosclerotic lesion area at the aortic root of Ldlr -/- mice ( n = 7,8,8; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). i Correlation between serum total cholesterol levels and atherosclerotic lesion sizes in Ldlr -/- mice ( n = 16; Correlation was analyzed by Pearson correlation). j Representative images of immunofluorescence staining of CD68 (green) and α-smooth muscle actin (αSMA) (red) at the aortic root of Ldlr -/- mice (scale bar=200 µm). Quantitative analysis of staining area is displayed as indicated ( n = 6,6,6; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). k The expression levels of hepatic lipogenic genes of HCD-fed Ldlr -/- mice treated with tsRNA-Glu-CTC ASO or control ASO were analyzed by quantitative real-time PCR ( n = 6, mean ± SEM, two-tailed Student’s t-test). n represents the number of biological replicates (mice). VLDL-C very low-density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol.
Normal Rodent Diet (Nd: Envigo 2018s), supplied by Envigo, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+diet+nd/pmc11965330-458-20-24?v=Envigo
Average 90 stars, based on 1 article reviews
normal rodent diet (nd: envigo 2018s) - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier
picolab rodent diet 20 5053  (PMI Nutrition International LLC)
99
PMI Nutrition International LLC picolab rodent diet 20 5053
Seven-week-old male Ldl receptor -deficient ( Ldlr -/- ) mice were treated with tsRNA-Glu-CTC antisense oligonucleotides (ASO) or control ASO twice per week for 7 weeks. The mice were maintained on a <t>normal</t> <t>chow</t> <t>diet</t> (ND) or switched to a high-cholesterol diet (HCD) starting at 8-week-old age. a The schematic of tsRNA-Glu-CTC ASO treatment experiment. Created in BioRender. Zhou, C. ( https://BioRender.com/rj9jwzr ). b – g Body weight ( n = 8,10,10) ( b ), representative photos of collected serum ( c ), serum total cholesterol ( n = 8,10,10) (left panel) and triglyceride ( n = 5,10,10) (right panel) levels ( d ), cholesterol levels of lipoprotein fractions (VLDL-C, LDL-C, and HDL-C) ( n = 8,10,10) ( e ), representative Oil-Red-O (top) and hematoxylin and eosin (bottom) stained liver sections (scale bar =100 μm) ( f ), and hepatic cholesterol ( n = 6,9,6) (left panel) and triglyceride ( n = 6,8,6) (right panel) contents ( g ) of Ldlr -/- mice treated with vehicle control, control ASO, or tsRNA-Glu-CTC ASO (data are shown as mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). h Representative images of Oil-red-O-stained sections and quantitative analysis of the atherosclerotic lesion area at the aortic root of Ldlr -/- mice ( n = 7,8,8; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). i Correlation between serum total cholesterol levels and atherosclerotic lesion sizes in Ldlr -/- mice ( n = 16; Correlation was analyzed by Pearson correlation). j Representative images of immunofluorescence staining of CD68 (green) and α-smooth muscle actin (αSMA) (red) at the aortic root of Ldlr -/- mice (scale bar=200 µm). Quantitative analysis of staining area is displayed as indicated ( n = 6,6,6; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). k The expression levels of hepatic lipogenic genes of HCD-fed Ldlr -/- mice treated with tsRNA-Glu-CTC ASO or control ASO were analyzed by quantitative real-time PCR ( n = 6, mean ± SEM, two-tailed Student’s t-test). n represents the number of biological replicates (mice). VLDL-C very low-density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol.
Picolab Rodent Diet 20 5053, supplied by PMI Nutrition International LLC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+diet+nd/custom%405053%4011751097?v=PMI+Nutrition+International+LLC
Average 99 stars, based on 1 article reviews
picolab rodent diet 20 5053 - by Bioz Stars, 2026-07
99/100 stars
  Buy from Supplier
normal diet (nd  (Trouw Nutrition USA LLC)
90
Trouw Nutrition USA LLC normal diet (nd
Seven-week-old male Ldl receptor -deficient ( Ldlr -/- ) mice were treated with tsRNA-Glu-CTC antisense oligonucleotides (ASO) or control ASO twice per week for 7 weeks. The mice were maintained on a <t>normal</t> <t>chow</t> <t>diet</t> (ND) or switched to a high-cholesterol diet (HCD) starting at 8-week-old age. a The schematic of tsRNA-Glu-CTC ASO treatment experiment. Created in BioRender. Zhou, C. ( https://BioRender.com/rj9jwzr ). b – g Body weight ( n = 8,10,10) ( b ), representative photos of collected serum ( c ), serum total cholesterol ( n = 8,10,10) (left panel) and triglyceride ( n = 5,10,10) (right panel) levels ( d ), cholesterol levels of lipoprotein fractions (VLDL-C, LDL-C, and HDL-C) ( n = 8,10,10) ( e ), representative Oil-Red-O (top) and hematoxylin and eosin (bottom) stained liver sections (scale bar =100 μm) ( f ), and hepatic cholesterol ( n = 6,9,6) (left panel) and triglyceride ( n = 6,8,6) (right panel) contents ( g ) of Ldlr -/- mice treated with vehicle control, control ASO, or tsRNA-Glu-CTC ASO (data are shown as mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). h Representative images of Oil-red-O-stained sections and quantitative analysis of the atherosclerotic lesion area at the aortic root of Ldlr -/- mice ( n = 7,8,8; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). i Correlation between serum total cholesterol levels and atherosclerotic lesion sizes in Ldlr -/- mice ( n = 16; Correlation was analyzed by Pearson correlation). j Representative images of immunofluorescence staining of CD68 (green) and α-smooth muscle actin (αSMA) (red) at the aortic root of Ldlr -/- mice (scale bar=200 µm). Quantitative analysis of staining area is displayed as indicated ( n = 6,6,6; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). k The expression levels of hepatic lipogenic genes of HCD-fed Ldlr -/- mice treated with tsRNA-Glu-CTC ASO or control ASO were analyzed by quantitative real-time PCR ( n = 6, mean ± SEM, two-tailed Student’s t-test). n represents the number of biological replicates (mice). VLDL-C very low-density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol.
Normal Diet (Nd, supplied by Trouw Nutrition USA LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+diet+nd/pmc11798413-61-41-52?v=Trouw+Nutrition+USA+LLC
Average 90 stars, based on 1 article reviews
normal diet (nd - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier

Image Search Results


Seven-week-old male Ldl receptor -deficient ( Ldlr -/- ) mice were treated with tsRNA-Glu-CTC antisense oligonucleotides (ASO) or control ASO twice per week for 7 weeks. The mice were maintained on a normal chow diet (ND) or switched to a high-cholesterol diet (HCD) starting at 8-week-old age. a The schematic of tsRNA-Glu-CTC ASO treatment experiment. Created in BioRender. Zhou, C. ( https://BioRender.com/rj9jwzr ). b – g Body weight ( n = 8,10,10) ( b ), representative photos of collected serum ( c ), serum total cholesterol ( n = 8,10,10) (left panel) and triglyceride ( n = 5,10,10) (right panel) levels ( d ), cholesterol levels of lipoprotein fractions (VLDL-C, LDL-C, and HDL-C) ( n = 8,10,10) ( e ), representative Oil-Red-O (top) and hematoxylin and eosin (bottom) stained liver sections (scale bar =100 μm) ( f ), and hepatic cholesterol ( n = 6,9,6) (left panel) and triglyceride ( n = 6,8,6) (right panel) contents ( g ) of Ldlr -/- mice treated with vehicle control, control ASO, or tsRNA-Glu-CTC ASO (data are shown as mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). h Representative images of Oil-red-O-stained sections and quantitative analysis of the atherosclerotic lesion area at the aortic root of Ldlr -/- mice ( n = 7,8,8; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). i Correlation between serum total cholesterol levels and atherosclerotic lesion sizes in Ldlr -/- mice ( n = 16; Correlation was analyzed by Pearson correlation). j Representative images of immunofluorescence staining of CD68 (green) and α-smooth muscle actin (αSMA) (red) at the aortic root of Ldlr -/- mice (scale bar=200 µm). Quantitative analysis of staining area is displayed as indicated ( n = 6,6,6; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). k The expression levels of hepatic lipogenic genes of HCD-fed Ldlr -/- mice treated with tsRNA-Glu-CTC ASO or control ASO were analyzed by quantitative real-time PCR ( n = 6, mean ± SEM, two-tailed Student’s t-test). n represents the number of biological replicates (mice). VLDL-C very low-density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol.

Journal: Nature Communications

Article Title: A cholesterol-responsive hepatic tRNA-derived small RNA regulates cholesterol homeostasis and atherosclerosis development

doi: 10.1038/s41467-025-67387-z

Figure Lengend Snippet: Seven-week-old male Ldl receptor -deficient ( Ldlr -/- ) mice were treated with tsRNA-Glu-CTC antisense oligonucleotides (ASO) or control ASO twice per week for 7 weeks. The mice were maintained on a normal chow diet (ND) or switched to a high-cholesterol diet (HCD) starting at 8-week-old age. a The schematic of tsRNA-Glu-CTC ASO treatment experiment. Created in BioRender. Zhou, C. ( https://BioRender.com/rj9jwzr ). b – g Body weight ( n = 8,10,10) ( b ), representative photos of collected serum ( c ), serum total cholesterol ( n = 8,10,10) (left panel) and triglyceride ( n = 5,10,10) (right panel) levels ( d ), cholesterol levels of lipoprotein fractions (VLDL-C, LDL-C, and HDL-C) ( n = 8,10,10) ( e ), representative Oil-Red-O (top) and hematoxylin and eosin (bottom) stained liver sections (scale bar =100 μm) ( f ), and hepatic cholesterol ( n = 6,9,6) (left panel) and triglyceride ( n = 6,8,6) (right panel) contents ( g ) of Ldlr -/- mice treated with vehicle control, control ASO, or tsRNA-Glu-CTC ASO (data are shown as mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). h Representative images of Oil-red-O-stained sections and quantitative analysis of the atherosclerotic lesion area at the aortic root of Ldlr -/- mice ( n = 7,8,8; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). i Correlation between serum total cholesterol levels and atherosclerotic lesion sizes in Ldlr -/- mice ( n = 16; Correlation was analyzed by Pearson correlation). j Representative images of immunofluorescence staining of CD68 (green) and α-smooth muscle actin (αSMA) (red) at the aortic root of Ldlr -/- mice (scale bar=200 µm). Quantitative analysis of staining area is displayed as indicated ( n = 6,6,6; mean ± SEM, one-way ANOVA, Bonferroni multiple-comparison test). k The expression levels of hepatic lipogenic genes of HCD-fed Ldlr -/- mice treated with tsRNA-Glu-CTC ASO or control ASO were analyzed by quantitative real-time PCR ( n = 6, mean ± SEM, two-tailed Student’s t-test). n represents the number of biological replicates (mice). VLDL-C very low-density lipoprotein cholesterol; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol.

Article Snippet: The mice were either fed a normal chow diet (ND) (LabDiet, PicoLab Rodent Diet 5053) for 7 weeks or fed a ND for 1 week and then switched to a HCD for 6 weeks.

Techniques: Control, Staining, Comparison, Immunofluorescence, Expressing, Real-time Polymerase Chain Reaction, Two Tailed Test